Myrtle Island - Myrtle Island is a quaint area located in Bluffton. When you cross onto the island, it is like taking a step back in time, with lush vegetation blending harmoniously with the stunning views of the May River. This quiet, serene neighborhood lends itself to an unhurried lifestyle, one where neighbors become lifelong friends. The history of Myrtle Island is as rich and exciting as its scenery.